diff --git a/crates/cli-support/src/js/mod.rs b/crates/cli-support/src/js/mod.rs
index 4444d1ef..a26a489d 100644
--- a/crates/cli-support/src/js/mod.rs
+++ b/crates/cli-support/src/js/mod.rs
@@ -143,7 +143,8 @@ impl<'a> Context<'a> {
             | OutputMode::Node {
                 experimental_modules: true,
             }
-            | OutputMode::Web => {
+            | OutputMode::Web
+            | OutputMode::Deno => {
                 if contents.starts_with("function") {
                     let body = &contents[8..];
                     if export_name == definition_name {
@@ -269,6 +270,40 @@ impl<'a> Context<'a> {
         reset_indentation(&shim)
     }
 
+    // generates somthing like
+    // ```js
+    // const imports = {
+    //   __wbindgen_placeholder__: {
+    //     __wbindgen_throw: function(..) { .. },
+    //     ..
+    //   }
+    // }
+    // ```
+    fn generate_deno_imports(&self) -> String {
+        let mut imports = "const imports = {\n".to_string();
+        imports.push_str(&format!("  {}: {{\n", crate::PLACEHOLDER_MODULE));
+
+        for (id, js) in crate::sorted_iter(&self.wasm_import_definitions) {
+            let import = self.module.imports.get(*id);
+            imports.push_str(&format!("{}: {},\n", &import.name, js.trim()));
+        }
+
+        imports.push_str("\t}\n};\n\n");
+
+        imports
+    }
+
+    fn generate_deno_wasm_loading(&self, module_name: &str) -> String {
+        format!(
+            "const file = new URL(import.meta.url).pathname;
+            const wasmFile = file.substring(0, file.lastIndexOf(Deno.build.os === 'windows' ? '\\\\' : '/') + 1) + '{}_bg.wasm';
+            const wasmModule = new WebAssembly.Module(Deno.readFileSync(wasmFile));
+            const wasmInstance = new WebAssembly.Instance(wasmModule, imports);
+            const wasm = wasmInstance.exports;",
+            module_name
+        )
+    }
+
     /// Performs the task of actually generating the final JS module, be it
     /// `--target no-modules`, `--target web`, or for bundlers. This is the very
     /// last step performed in `finalize`.
@@ -331,6 +366,15 @@ impl<'a> Context<'a> {
                 }
             }
 
+            OutputMode::Deno => {
+                footer.push_str(&self.generate_deno_imports());
+                footer.push_str(&self.generate_deno_wasm_loading(module_name));
+
+                if needs_manual_start {
+                    footer.push_str("wasm.__wbindgen_start();\n");
+                }
+            }
+
             // With Bundlers and modern ES6 support in Node we can simply import
             // the wasm file as if it were an ES module and let the
             // bundler/runtime take care of it.
@@ -443,7 +487,8 @@ impl<'a> Context<'a> {
             | OutputMode::Node {
                 experimental_modules: true,
             }
-            | OutputMode::Web => {
+            | OutputMode::Web
+            | OutputMode::Deno => {
                 for (module, items) in crate::sorted_iter(&self.js_imports) {
                     imports.push_str("import { ");
                     for (i, (item, rename)) in items.iter().enumerate() {
@@ -1247,7 +1292,7 @@ impl<'a> Context<'a> {
                 fields: Vec::new(),
             })?;
             self.global(&format!("let cached{} = new {}{};", s, name, args));
-        } else if !self.config.mode.always_run_in_browser() {
+        } else if !self.config.mode.always_run_in_browser() && !self.config.mode.deno() {
             self.global(&format!(
                 "
                     const l{0} = typeof {0} === 'undefined' ? \
diff --git a/crates/cli-support/src/lib.rs b/crates/cli-support/src/lib.rs
index dd2979f1..ffbed9c1 100755
--- a/crates/cli-support/src/lib.rs
+++ b/crates/cli-support/src/lib.rs
@@ -74,6 +74,7 @@ enum OutputMode {
     Web,
     NoModules { global: String },
     Node { experimental_modules: bool },
+    Deno,
 }
 
 enum Input {
@@ -210,6 +211,14 @@ impl Bindgen {
         Ok(self)
     }
 
+    pub fn deno(&mut self, deno: bool) -> Result<&mut Bindgen, Error> {
+        if deno {
+            self.switch_mode(OutputMode::Deno, "--target deno")?;
+            self.encode_into(EncodeInto::Always);
+        }
+        Ok(self)
+    }
+
     pub fn no_modules_global(&mut self, name: &str) -> Result<&mut Bindgen, Error> {
         match &mut self.mode {
             OutputMode::NoModules { global } => *global = name.to_string(),
@@ -526,7 +535,8 @@ impl OutputMode {
             | OutputMode::Web
             | OutputMode::Node {
                 experimental_modules: true,
-            } => true,
+            }
+            | OutputMode::Deno => true,
             _ => false,
         }
     }
@@ -570,6 +580,13 @@ impl OutputMode {
         }
     }
 
+    fn deno(&self) -> bool {
+        match self {
+            OutputMode::Deno { .. } => true,
+            _ => false,
+        }
+    }
+
     fn esm_integration(&self) -> bool {
         match self {
             OutputMode::Bundler { .. }
diff --git a/crates/cli/src/bin/wasm-bindgen.rs b/crates/cli/src/bin/wasm-bindgen.rs
index 9e9969a6..6a633c0b 100644
--- a/crates/cli/src/bin/wasm-bindgen.rs
+++ b/crates/cli/src/bin/wasm-bindgen.rs
@@ -22,7 +22,7 @@ Options:
     --out-dir DIR                Output directory
     --out-name VAR               Set a custom output filename (Without extension. Defaults to crate name)
     --target TARGET              What type of output to generate, valid
-                                 values are [web, bundler, nodejs, no-modules],
+                                 values are [web, bundler, nodejs, no-modules, deno],
                                  and the default is [bundler]
     --no-modules-global VAR      Name of the global variable to initialize
     --browser                    Hint that JS should only be compatible with a browser
@@ -98,6 +98,7 @@ fn rmain(args: &Args) -> Result<(), Error> {
             "web" => b.web(true)?,
             "no-modules" => b.no_modules(true)?,
             "nodejs" => b.nodejs(true)?,
+            "deno" => b.deno(true)?,
             s => bail!("invalid encode-into mode: `{}`", s),
         };
     }